RET/TRKA-IN-1

RET/TRKA-IN-1 (Compound 13) is a dual inhibitor targeting RET with an IC50 of 0.375 μM and TRKA. It reduces cell viability of LC-2 and KM12, with GI50 values of 0.72 and 0.25 μM respectively. RET/TRKA-IN-1 also induces cell cycle arrest at the G1 phase.