RET/TRKA-IN-1
RET/TRKA-IN-1 (Compound 13) is a dual inhibitor targeting RET with an IC50 of 0.375 μM and TRKA. It reduces cell viability of LC-2 and KM12, with GI50 values of 0.72 and 0.25 μM respectively. RET/TRKA-IN-1 also induces cell cycle arrest at the G1 phase.
Product Specifications
CAS Number
3048634-52-9
Field of Research
Cell Biology, Signal Transduction
Smiles
O=C (NC1=CC (=NN1C) C (C) (C) C) CC2=CC=C (C=C2) NC=3N=CN=C4NC5=CC (=CC=C5C34) C=6C=NN (C6) C
Molecular Formula
C30H31N9O
Molecular Weight
533.63
Storage Conditions
-20°C
Notes
For research use only.
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