Sheep Human Factor I Antibody

Precipitating polyclonal sheep antiserum to human factor I. Factor I is a serine protease composed of two disulphide-linked chains. The protein has a molecular weight of 88.000 and its mean concentration in human plasma is 35 mg/ml. It is involved in the regulation of the C3/C5 convertase of either pathway. Using C4-binding protein or factor H splits the a chains of C4b or C3b respectively, which includes their roles in the C3/C5 convertases. It has been isolated as a homogenous protein for use in the antiserum production. Freund's complete adjuvant is used in the first step of the immunization procedure.

Product Specifications

UniProt

P05156

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Source

Factor I is a serine protease composed of two disulphide-linked chains. The protein has a molecular weight of 88.000 and its mean concentration in human plasma is 35 μg/ml. It is involved in the regulation of the C3/C5 convertase of either pathway. Using C4-binding protein or factor H splits the a chains of C4b or C3b respectively, which includes their roles in the C3/C5 convertases. It has been isolated as a homogenous protein for use in the antiserum production. Freund’s complete adjuvant is used in the first step of the immunization procedure.

Field of Research

Epigenetics, Immunology, Infectious Diseases

Form

Delipidated, heat inactivated, lyophilized, stable IgG fraction. No preservative added. Total protein and IgG concentration are comparable to those of pooled normal sheep serum. No foreign proteins added.