Reversine
Reversine is a novel class of ATP-competitive Aurora kinase inhibitor with IC50s of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively.
Product Specifications
CAS Number
656820-32-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aurora Kinase; Autophagy
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/reversine.html
Concentration
10mM
Purity
99.22
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
C1(NC2=CC=C(N3CCOCC3)C=C2)=NC(NC4CCCCC4)=C5C(NC=N5)=N1
Molecular Formula
C21H27N7O
Molecular Weight
393.49
Precautions
H302, H315, H319, H335
References & Citations
[1]D'Alise AM, et al. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol Cancer Ther. 2008 May;7 (5) :1140-9.|[2]Qin HX, et al. Synergistic antitumor activity of reversine combined with aspirin in cervical carcinoma in vitro and in vivo. Cytotechnology. 2013 Aug;65 (4) :643-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B; Aurora C
Available Sizes
Frequently Asked Questions
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