Reversine

Reversine is a novel class of ATP-competitive Aurora kinase inhibitor with IC50s of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively.

Product Specifications

CAS Number

[656820-32-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aurora Kinase; Autophagy

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/reversine.html

Concentration

10mM

Purity

99.22

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

C1(NC2=CC=C(N3CCOCC3)C=C2)=NC(NC4CCCCC4)=C5C(NC=N5)=N1

Molecular Formula

C21H27N7O

Molecular Weight

393.49

Precautions

H302, H315, H319, H335

References & Citations

[1]D'Alise AM, et al. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol Cancer Ther. 2008 May;7 (5) :1140-9.|[2]Qin HX, et al. Synergistic antitumor activity of reversine combined with aspirin in cervical carcinoma in vitro and in vivo. Cytotechnology. 2013 Aug;65 (4) :643-53.