Apalcillin
Apalcillin (PC-904) combined with Ro 48-1220 (a penicillin sulfone β-lactamase inhibitor) exhibits broad-spectrum activity against Gram-negative aerobic and anaerobic bacteria, excluding Klebsiella acid-producing strains. This combination shows strong efficacy against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae with an effective MIC of 11 μg/mL. Additionally, it inhibits Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter at low MICs (0.25 to 4 μg/mL) . However, it has limited efficacy against oxacillin-resistant staphylococci and some Gram-positive bacteria. Apalcillin/Ro 48-1220's effectiveness against certain extended-spectrum β-lactamase-producing Escherichia coli is comparable to piperacillin/tazobactam, though it is less effective against SHV-type β-lactamases.
Product Specifications
CAS Number
63469-19-2
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery
Smiles
N (C ([C@H] (NC (=O) C1=C (O) C2=C (N=C1) C=CC=N2) C3=CC=CC=C3) =O) [C@H]4[C@@]5 (N ([C@@H] (C (O) =O) C (C) (C) S5) C4=O) [H]
Molecular Formula
C25H23N5O6S
Molecular Weight
521.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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