SRI-31142
SRI-31142 is a proposed brain-penetrant allosteric inhibitor of the dopamine transporter (DAT) . In behavioral studies utilizing intracranial self-stimulation (ICSS), SRI-31142 does not produce the abuse-related effects observed with cocaine and GBR-12935. Instead, at effective doses, it reduces ICSS responding and dopamine levels in the nucleus accumbens (NAc) . Additionally, SRI-31142 can prevent cocaine-induced increases in ICSS and NAc dopamine.
Product Specifications
CAS Number
1940118-04-6
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
N=1C=CC (=CC1) C (C=2C=CC=CC2) CNC3=NC (=NC=4C=CC=CC43) C5=CN6C=CN=C6C=C5C
Molecular Formula
C29H24N6
Molecular Weight
456.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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