HDAC6-IN-45
HDAC6-IN-45 (Compound 15) is a selective inhibitor of HDAC6, with an IC50 of 15.2 nM. It exerts neurotrophic effects by upregulating GAP43 and Beta-3 Tubulin markers. Additionally, HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, and inhibits apoptosis in PC12 cells. In zebrafish models of Alzheimer's disease, it demonstrates neuroprotective properties. Moreover, HDAC6-IN-45 exhibits antioxidant activity and has favorable blood-brain barrier (BBB) permeability.
Product Specifications
CAS Number
3048532-05-1
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Signal Transduction
Smiles
O=C (NO) C1=CC=C (C=C1) CN2CC3=C (C=4C=C (F) C=CC4N3CC5CC5) CC2
Molecular Formula
C23H24FN3O2
Molecular Weight
393.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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