Human CDC42 Protein

<strong>Human CDC42 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011900_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> CDC 42 protein, G25K protein, CDC-42 protein, CDC 42, Small GTP binding protein CDC42., Cell division cycle 42 protein, Cell division cycle 42 isoform 1 CDC42Hs protein, CDC42, CDC-42_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Maldonado MDM, Dharmawardhane S. Targeting Rac and Cdc42 GTPases in Cancer Cancer Res. 2018 Jun 15;78(12):3101-3111._x000D_ 2: Mosaddeghzadeh N, Ahmadian MR. The RHO Family GTPases: Mechanisms of Regulation and Signaling Cells. 2021 Jul 20;10(7):1831._x000D_ 3: Su HC, Orange JS. The Growing Spectrum of Human Diseases Caused by Inherited CDC42 Mutations J Clin Immunol. 2020 May;40(4):551-553._x000D_ 4: Unbekandt M, Lilla S, Zanivan S, Olson MF. The CDC42 effector protein MRCKβ autophosphorylates on Threonine 1108 Small GTPases. 2020 Nov;11(6):451-460._x000D_ 5: Cao J, Zhang C, Jiang GQ, Jin SJ, Wang Q, Wang AQ, Bai DS. Identification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses Bioengineered. 2021 Dec;12(1):296-309._x000D_ 6: Martinelli S, Krumbach OHF, Pantaleoni F, Coppola S, Amin E, Pannone L, Nouri K, Farina L, Dvorsky R, Lepri F, Buchholzer M, Konopatzki R, Walsh L, Payne K, Pierpont ME, Vergano SS, Langley KG, Larsen D, Farwell KD, Tang S, Mroske C, Gallotta I, Di Schiavi E, Della Monica M, Lugli L, Rossi C, Seri M, Cocchi G, Henderson L, Baskin B, Alders M, Mendoza-Londono R, Dupuis L, Nickerson DA, Chong JX; University of Washington Center for Mendelian Genomics, Meeks N, Brown K, Causey T, Cho MT, Demuth S, Digilio MC, Gelb BD, Bamshad MJ, Zenker M, Ahmadian MR, Hennekam RC, Tartaglia M, Mirzaa GM. Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes Am J Hum Genet. 2018 Feb 1;102(2):309-320._x000D_ 7: Lam MT, Coppola S, Krumbach OHF, Prencipe G, Insalaco A, Cifaldi C, Brigida I, Zara E, Scala S, Di Cesare S, Martinelli S, Di Rocco M, Pascarella A, Niceta M, Pantaleoni F, Ciolfi A, Netter P, Carisey AF, Diehl M, Akbarzadeh M, Conti F, Merli P, Pastore A, Levi Mortera S, Camerini S, Farina L, Buchholzer M, Pannone L, Cao TN, Coban-Akdemir ZH, Jhangiani SN, Muzny DM, Gibbs RA, Basso-Ricci L, Chiriaco M, Dvorsky R, Putignani L, Carsetti R, Janning P, Stray-Pedersen A, Erichsen HC, Horne A, Bryceson YT, Torralba-Raga L, Ramme K, Rosti V, Bracaglia C, Messia V, Palma P, Finocchi A, Locatelli F, Chinn IK, Lupski JR, Mace EM, Cancrini C, Aiuti A, Ahmadian MR, Orange JS, De Benedetti F, Tartaglia M. A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function J Exp Med. 2019 Dec 2;216(12):2778-2799._x000D_ 8: Murphy NP, Mott HR, Owen D. Progress in the therapeutic inhibition of Cdc42 signalling Biochem Soc Trans. 2021 Jun 30;49(3):1443-1456._x000D_ 9: Shiraishi A, Uruno T, Sanematsu F, Ushijima M, Sakata D, Hara T, Fukui Y. DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction J Biol Chem. 2017 Feb 10;292(6):2191-2202._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31469028">10: Reinhard NR, Van Der Niet S, Chertkova A, Postma M, Hordijk PL, Gadella TWJ Jr, Goedhart J. Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells Small GTPases. 2021 May;12(3):226-240. </a>_x000D_ _x000D_ <strong>Products Related to Human CDC42 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>