LDR102
LDR102 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki value of 0.10 μM. LDR102 inhibits the proliferation of the cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. LDR102 has demonstrated antitumor activity in mouse models and exhibits favorable pharmacokinetic properties in rats.
Product Specifications
CAS Number
3053223-31-4
Field of Research
Metabolism Research, Stem Cell & Developmental Biology
Purity
99.52% (May vary between batches)
Smiles
O=C (NC=1C=CC=2C (=CN (C2C1) C) C=3C=CC (OCOC) =CC3) C4=CC=C (C (C#CC5=CC=NC=6NN=CC56) =C4) C
Molecular Formula
C33H27N5O3
Molecular Weight
541.6
Storage Conditions
-20°C
Notes
For research use only.
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