Antitumor agent-177
Antitumor agent-177 (compound 57) is a non-steroidal NSC12 derivative exhibiting strong affinity for FGF2, with a Kd of 24 μM determined by SPR. It significantly inhibits the formation of the HSPG/FGF2/FGFR1 ternary complex. This compound effectively suppresses FGFR activation in multiple myeloma (MM) cells and demonstrates potent antitumor activity both in vitro and in vivo.
Product Specifications
Field of Research
Cardiovascular Research, Signal Transduction
Molecular Formula
C28H21F7O4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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