SPDZi1

SPDZi1 is a potent and selective inhibitor of syntenin, binding to the PDZ1 and PDZ2 domains of syntenin. It shows an affinity for the syntenin PDZ tandem (STNPDZ) with a dissociation constant (Kd) of 3.6 μM. Additionally, SPDZi1 inhibits glioblastoma and reduces the activity of NF-κB [a downstream effector of syntenin].