PROTAC SOS1 degrader-10
PROTACSOS1 degrader-10 (Compound 11o) is a degrader of son of sevenless 1 (SOS1) that functions through CRBN- and protease-dependent mechanisms. It effectively degrades SOS1 in KRAS-mutated cancer cells SW620, A549, and DLD-1, with DC50 values of 2.23, 1.85, and 7.53 nM, respectively. Additionally, PROTACSOS1 degrader-10 inhibits the proliferation of SW620, A549, and DLD-1 cells, with IC50 values of 36.7, 52.2, and 107 nM, and suppresses ERK phosphorylation.
Product Specifications
CAS Number
3043923-74-3
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (=O) (N1CCC2 (CC1) CCC (CN3CCN (C (=O) [C@@H]4CC[C@H] (CC4) C5=CC=6C (N (C) C5=O) =NC=NC6N[C@H] (C) C7=CC (C (F) (F) F) =CC (N) =C7) CC3) CC2) C8=CC (=C (OC) C=C8) N9C (=O) NC (=O) CC9
Molecular Formula
C51H63F3N10O6
Molecular Weight
969.10
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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