Bimoclomol
Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases.
Product Specifications
CAS Number
[130493-03-7]
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Bimoclomol.html
Purity
99.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Cl/C(C1=CC=CN=C1)=N\OCC(O)CN2CCCCC2
Molecular Formula
C14H20ClN3O2
Molecular Weight
297.78
References & Citations
[1]Jednakovits A, et al. In vivo and in vitro acute cardiovascular effects of bimoclomol. Gen Pharmacol. 2000 May;34 (5) :363-9.|[2]Hargitai J, et al. Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun. 2003 Aug 1;307 (3) :689-95.|[3]Polakowski JS, et al. Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Eur J Pharmacol. 2002 Jan 18;435 (1) :73-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
HSP
Available Sizes
Curated Selection
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