Dual AChE-MAO B-IN-4

Dual AChE-MAO B-IN-4 (compound 7) is a dual inhibitor of AChE and MAO-B, with IC50 values of 261 nM and 15 nM, respectively. It offers protection against oxidative damage induced by H2O2 and 6-OHDA in SH-SY5Y cells and can penetrate the central nervous system in a model simulating the blood-brain barrier. This compound is applicable in research on neurological disorders such as Alzheimer's disease (AD) .