ML179
ML179 (SR-1309) is a inverse LRH1/NR5A2 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer[1].
Product Specifications
CAS Number
[1883548-87-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml179.html
Purity
99.73
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1C2CCCCC2)C=C(NC1=O)N3CCN(CC3)C4=CC=CC(C(F)(F)F)=C4
Molecular Formula
C21H25F3N4O2
Molecular Weight
422.44
Precautions
H302, H315, H319
References & Citations
[1]Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2) . 2010 Oct 12 [updated 2011 Dec 12].
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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