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AT1R antagonist 3

AT1R antagonist 3 (Compound 1) is an antagonist of the angiotensin II type 1 receptor (AT1R) and an inhibitor of the L-type calcium channel CaV1.2 (IC50=0.57 μM) . It exhibits vasodilatory effects in isolated rat aorta (10 μM, 88.7%) and shows antihypertensive activity in rat models.

Product Specifications

CAS Number

3053482-15-5

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Smiles

O=C (O) C=1C=CC=2N=C (SCC=3C=CC (=CC3) C=4C=CC=CC4C5=NN=NN5) NC2C1

Molecular Formula

C22H16N6O2S

Molecular Weight

428.47

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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