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Nurr1 agonist 9

Nurr1 agonist 9 (Compound 36) acts as an agonist for Nurr1, with an EC50 of 0.090 μM and a Kd of 0.17 μM. It activates Nurr1 homodimers (NurRE, EC50 = 0.094 μM) and Nurr1-RXR heterodimers (DR5, EC50 = 0.165 μM) . This compound induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in Parkinson's disease organoid models and can penetrate the human brain endothelial cell barrier.

Product Specifications

Field of Research

Cancer Biology; Pharmacology & Drug Discovery, Metabolism Research

Molecular Formula

C21H19ClN4O2

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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