AS-136A
AS-136A is an orally active non-nucleoside inhibitor of the measles virus RNA-dependent RNA polymerase (RdRp) with an IC50 of 2 µM for measles virus[1].
Product Specifications
CAS Number
[949898-66-2]
UNSPSC
12352005
Hazard Statement
H302, H319
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/as-136a.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(C(F)(F)F)=NN1C)NC2=CC=C(S(=O)(N3CCCCC3)=O)C=C2
Molecular Formula
C17H19F3N4O3S
Molecular Weight
416.42
Precautions
H302, H319
References & Citations
[1]Ndungu JM, et al. Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics. J Med Chem. 2012;55 (9) :4220-4230.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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