AS-136A

AS-136A is an orally active non-nucleoside inhibitor of the measles virus RNA-dependent RNA polymerase (RdRp) with an IC50 of 2 µM for measles virus[1].

Product Specifications

CAS Number

[949898-66-2]

UNSPSC

12352005

Hazard Statement

H302, H319

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/as-136a.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC(C(F)(F)F)=NN1C)NC2=CC=C(S(=O)(N3CCCCC3)=O)C=C2

Molecular Formula

C17H19F3N4O3S

Molecular Weight

416.42

Precautions

H302, H319

References & Citations

[1]Ndungu JM, et al. Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics. J Med Chem. 2012;55 (9) :4220-4230.