NF449
NF449 is a potent antagonist of the P2X1 receptor, displaying IC50 values of 0.28 nM, 0.69 nM, and 120 nM for rP2X1, rP2X1+5, and P2X2+3, respectively. It acts selectively against Gsα G proteins (G Protein) . NF449 inhibits the binding rate of GTP[γS] to Gsα-s, suppresses the stimulation of adenylate cyclase activity, and blocks the coupling of β-adrenergic receptors with Gs.
Product Specifications
CAS Number
389142-38-5
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C (NC=1C=C (C=C (C1) C (=O) NC2=CC=C (C=C2S (=O) (=O) O) S (=O) (=O) O) C (=O) NC3=CC=C (C=C3S (=O) (=O) O) S (=O) (=O) O) NC=4C=C (C=C (C4) C (=O) NC5=CC=C (C=C5S (=O) (=O) O) S (=O) (=O) O) C (=O) NC6=CC=C (C=C6S (=O) (=O) O) S (=O) (=O) O
Molecular Formula
C41H32N6O29S8
Molecular Weight
1329.24
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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MBS6248866-01 0.1 mL
Crystallin, alpha B (alpha B Crystallin Protein, Alpha(B) Crystallin, Alpha Crystallin B Chain, CRYAB, Crystallin alpha 2, CRYA2, CTPP2, Heat Shock 20kD Like Protein, Heat Shock Protein beta 5, HSPB5, NY-REN 27 Antigen, Renal Carcinoma Antigen NY-REN-27,
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Crystallin, alpha B (alpha B Crystallin Protein, Alpha(B) Crystallin, Alpha Crystallin B Chain, CRYAB, Crystallin alpha 2, CRYA2, CTPP2, Heat Shock 20kD Like Protein, Heat Shock Protein beta 5, HSPB5, NY-REN 27 Antigen, Renal Carcinoma Antigen NY-REN-27,
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