16 (R) -AFP 07 free acid
Prostaglandin I2 is an unstable prostaglandin compound that inhibits platelet aggregation and induces vasodilation in the pulmonary vasculature via the "I prostanoid" (IP) receptor. AFP 07, a 7,7-difluoroprostacyclin derivative, serves as a selective and potent agonist for the IP receptor (Ki=0.561 nM) . It exhibits weaker affinity for EP receptors, with a Ki value of > 100 nM for EP1-3 and > 10 nM for EP4. The compound 16 (R) -AFP 07 free acid is an enantiomer of AFP 07. Its biological properties, particularly those involving IP and EP receptors, are yet to be fully assessed.
Product Specifications
CAS Number
773825-80-2
Field of Research
Cancer Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Smiles
C (=C/[C@@H] ([C@H] (CC#CCC) C) O) \[C@@H]1[C@@]2 ([C@@] (O/C (=C\CCCC (O) =O) /C2 (F) F) (C[C@H]1O) [H]) [H]
Molecular Formula
C22H30F2O5
Molecular Weight
412.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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