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Ru-Poma

Ru-Poma is an Ru (II) -based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.

Product Specifications

Field of Research

Cell Biology, Pharmacology & Drug Discovery

Molecular Formula

C89H75Cl2N11O11Ru.7H2O

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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