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GT-653

GT-653 is a PROTAC degrader targeting lysine-specific demethylase 5B (KDM5B) . It induces the degradation of KDM5B via ubiquitin-proteasome pathways, achieving a degradation rate of 68.35% at a concentration of 10 μM. Additionally, GT-653 upregulates H3K4me3 levels and activates type I interferon signaling pathways in prostate cancer cells 22RV1.

Product Specifications

Field of Research

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Molecular Formula

C32H27N7O9

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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