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Acetylcholine (chloride)

Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) [1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

Product Specifications

CAS Number

[60-31-1]

Product Name Alternative

ACh (chloride)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; Endogenous Metabolite; nAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Acetylcholine-chloride.html

Purity

99.91

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(OCC[N+](C)(C)C)C.[Cl-]

Molecular Formula

C7H16ClNO2

Molecular Weight

181.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3 (5) : 413-420.|[2]A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31 (2) :162-9.|[3]Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300 (7) :335-41.|[4]P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150 (3) :340-2.|[5]Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24 (4) :353-357.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Human Endogenous Metabolite

Citation 01

ACS Pharmacol Transl Sci. 2025 Jun 6;8 (7) :2048-2060.|Acta Pharmacol Sin. 2025 Aug;46 (8) :2151-2162.|Biochim Biophys Acta Mol Basis Dis. 2024 Aug 30:167488.|Biomed Pharmacother. 2024 Jul 12:177:117105.|bioRxiv. 2023 Oct 13.|BMC Pulm Med. 2021 Jun 5;21 (1) :189.|Cancer Cell. 2025 Aug 12:S1535-6108 (25) 00330-7.|Cells. 2024 Oct 14;13 (20) :1697.|Clin Exp Pharmacol Physiol. 2025 Nov;52 (11) :e70081.|Front Cardiovasc Med. 2021 Jun 16:8:679240.|J Ethnopharmacol. 2024 Aug 22:118707.|J Hazard Mater. 2024 Mar 5:465:133248.|J Hazard Mater. 2024 Sep 5:479:135690.|Mol Cell Endocrinol. 2025 Jan 21:599:112464.|Mol Metab. 2023 Dec:78:101811.|Proc Natl Acad Sci U S A. 2024 Jul 2;121 (27) :e2402143121.|Redox Biol. 2024 Feb:69:103004.|Res Sq. 2025 Nov 12.|Trends Biotechnol. 2025 Apr;43 (4) :918-945.|Turk J Med Sci. 2025 Feb 19;55 (2) :509-517. |Int J Mol Sci. 2023 Apr 16;24 (8) :7356.|Nat Commun. 2023 Sep 21;14 (1) :5891.|Neurosci Bull. 2025 Sep 18.

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