Isoniazid-d4

Isoniazid-d4 is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].

Product Specifications

CAS Number

[774596-24-6]

Product Name Alternative

INH-d4; Isonicotinic acid hydrazide-d4; Isonicotinic hydrazide-d4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Autophagy; Bacterial; Mitophagy

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Autophagy

Field of Research

Infection

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 33.33mg/mL (ultrasonic)

Smiles

NNC(C1=C([2H])C([2H])=NC([2H])=C1[2H])=O

Molecular Formula

C6H3D4N3O

Molecular Weight

141.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Suarez, J., et al., An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG) . J Biol Chem, 2009. 284 (11) : p. 7017-29.|[3]Timmins, G.S., et al., Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 2004. 48 (8) : p. 3006-9.|[4]Singh, R., et al., PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science, 2008. 322 (5906) : p. 1392-5.|[5]Ahmad, Z., et al., Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis, 2009. 200 (7) : p. 1136-43.