Phosphodiesterase-IN-2
Phosphodiesterase-IN-2 (Compound C7) is an orally active and selective inhibitor of phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. It enhances hepatic microsomal stability and reduces blood-brain barrier permeability. Phosphodiesterase-IN-2 exhibits favorable pharmacokinetic properties in mouse models and can alleviate isoprenaline-induced cardiac hypertrophy.
Product Specifications
CAS Number
3047610-96-5
Field of Research
Metabolism Research
Smiles
O=C (C1=CC (=NC=2C=CC=CC21) COC3=CC=C (C=C3) N4N=C (C=C4C=5C=CN=C (C5) C) C (F) (F) F) N6CC7 (CNC7) C6
Molecular Formula
C32H27F3N6O2
Molecular Weight
584.59
Storage Conditions
-20°C
Notes
For research use only.
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