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PROTAC TEAD degrader-1

PROTACTEAD degrader-1 (Compound 27) is a PROTAC degrader of the transcriptional enhanced associate domain (TEAD) . It selectively degrades Flag TEAD2 through a ubiquitin-protease-dependent mechanism, with a DC50 of 54.1 nM in 293T cells. This compound inhibits the proliferation of NF2-deficient NCI-H226 cells, showing an IC50 of 0.21 μM, and modulates the expression of yes-associated protein (YAP) target genes.

Product Specifications

Field of Research

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Molecular Formula

C44H41F3N6O7

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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