BTZO-1
BTZO-1, a chemical probe, binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE) -mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1].
Product Specifications
CAS Number
[99420-15-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Macrophage migration inhibitory factor (MIF)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/btzo-1.html
Purity
99.32
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=C1N=C(C2=NC=CC=C2)SC3=CC=CC=C13
Molecular Formula
C13H8N2OS
Molecular Weight
240.28
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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