Goat Monkey secretory component (free and bound) Antibody

Precipitating polyclonal goat antiserum to monkey secretory component. Secretory component is present in monkey secretions bound to secretory IgA (sIgA) and in free form. Secretory IgA (sIgA) functions as a dimer or polymer and accounts for almost all specific mucosal antibody activity. A molecule of sIgA is made up of two molecules of IgA, one J chain and one SC (MW 65,000) . The dimer IgA is transported into secretions by its binding to the SC on the epithelial cells. SC also has an affinity for polymeric IgM. Purified free secretory component isolated from pooled rhesus monkey milk is used for immunization. Freund's complete adjuvant is used in the first step of the immunization procedure.