Goat Human Factor XI Antibody

Factor XI is a glycoprotein (MW 160,000) composed of two identical polypeptide chains. In electrophoresis it migrates in the gamma region. It is stable on storage, heat \stable at 56oC for 30 minutes and not adsorbed by gels. Factor XI also occurs in platelets (MW 52,000) . Factor XI is converted to an active enzyme by FXIIa but can be activated by other proteases such as trypsin. FXIa activates FIX, but can also activate FXII and plasminogen. Platelet membrane FXI can substitute for plasma FXI in coagulation. Plasma FXI is used for immunization. Freund’s complete adjuvant is used in the first step of the immunization procedure.

Delipidated, heat inactivated, lyophilized, stable whole serum. No preservative added. Total protein and IgG concentrations in the antiserum are comparable to those of pooled normal goat serum. No foreign proteins added.