N-Propargylglycine
N-Propargylglycine is an orally active irreversible inhibitor of proline dehydrogenase (PRODH) . N-Propargylglycine has antitumor activity and can be used in the study of neurodegenerative diseases[1].
Product Specifications
CAS Number
[58160-95-5]
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/n-propargylglycine.html
Purity
99.70
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)CNCC#C
Molecular Formula
C5H7NO2
Molecular Weight
113.11
Precautions
H315, H319
References & Citations
[1]Scott GK, et al. N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. Amino Acids. 2021 Dec;53 (12) :1927-1939.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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