GSK0660

GSK0660 is a potent PPARβ antagonist with an IC50 of 155 nM.

Product Specifications

CAS Number

[1014691-61-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/GSK0660.html

Purity

99.49

Solubility

DMSO : ≥ 49 mg/mL

Smiles

O=C(C1=C(S(=O)(NC2=CC=C(NC3=CC=CC=C3)C=C2OC)=O)C=CS1)OC

Molecular Formula

C19H18N2O5S2

Molecular Weight

418.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Shearer BG, et al. Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. Mol Endocrinol. 2008 Feb;22 (2) :523-9. Epub 2007 Nov 1.|[2]Zhong X, et al. Bezafibrate enhances proliferation and differentiation of osteoblastic MC3T3-E1 cells via AMPK and eNOS activation. Acta Pharmacol Sin. 2011 May;32 (5) :591-600.|[3]Lee WJ, et al. Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells. J Cell Biochem. 2018 Feb 1.