PI4K-IN-1

PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/[1].

Product Specifications

CAS Number

[1800017-49-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K; PI4K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi4k-in-1.html

Purity

98.61

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC([C@@H](CC1)CC[C@H]1CNC2=NC3=CC=C(C4=CC(N(CC5CC5)C=C4)=O)C=C3S2)=O

Molecular Formula

C24H27N3O3S

Molecular Weight

437.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Raubo P, et al. Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα) . Bioorg Med Chem Lett. 2015 Aug 15;25 (16) :3189-93.