PD-1/PD-L1-IN-44

PD-1/PD-L1-IN-44 (Compound 22) selectively inhibits the PD-1/PD-L1 protein with an IC50 of 1.21 nM. In animal models, PD-1/PD-L1-IN-44 effectively suppressed tumor growth and increased CD8+ cell infiltration without exhibiting toxicity.