Antibacterial agent 205

Antibacterialagent 205 (Compound 10d) is an indole propene acyl-derived oxazaanthracene compound with a broad antibacterial spectrum, exhibiting a MIC of 0.25 to 0.5 μg/mL. It reduces extracellular polysaccharides and eliminates biofilms, thereby mitigating resistance. Antibacterialagent 205 exerts antibacterial effects by disrupting membrane integrity, accumulating reactive oxygen species (ROS), and inhibiting DNA replication.