Squalene synthase-IN-2

Squalene synthase-IN-2 (compound isomer A- (1S, 3R) -14i) is an orally active inhibitor of squalene synthase, with IC50 values of 3.4 nM for squalene synthase and 99 nM for cholesterol synthesis enzymes. Squalene synthase-IN-2 effectively reduces plasma cholesterol and triglycerides.