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AurkA allosteric-IN-1

AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor with an IC50 of 6.50 μM, which inhibits both the catalytic and non-catalytic activities of Aurora A. Aurora A is involved in the regulation of bipolar mitotic spindle assembly and the fidelity of chromosome segregation during mitosis. AurkA allosteric-IN-1 interferes with Aurora A by binding to the Y-pocket, thereby preventing its interaction with the activator TPX2.

Product Specifications

Field of Research

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Molecular Formula

C20H16N2O3

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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