PNK1 (phospho-Ser114/Thr118) rabbit pAb

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay. [provided by RefSeq, Sep 2010],

Product Specifications

Background

UniProt

Q96T60

Swiss Prot

Q96T60

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized phosho peptide around human PNK1 (Ser114 and Thr118)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Molecular Weight

57kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

57kD

Fragment

IgG

Subcellular Location

Nucleus . Chromosome . Localizes to site of double-strand breaks. .

Other Product Names

Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2' (3') -polynucleotidase) ; Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78) ]