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PNK1 (phospho-Ser114/Thr118) rabbit pAb

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay. [provided by RefSeq, Sep 2010],

Product Specifications

Background

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]

Synonyms

Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]

Gene ID

11284

UniProt

Q96T60

Cellular Locus

Nucleus. Chromosome. Localizes to site of double-strand breaks..

Host

Rabbit

Species Reactivity

Human,Rat,Mouse,

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized phosho peptide around human PNK1 (Ser114 and Thr118)

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, IHC

Validated Applications

WB,IHC

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

WB 1:500-2000; IHC-p 1:50-300

Molecular Weight

57kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES14048-1.pdf

Observed Molecular Weight

57 kD

Subcellular Location

Nucleus . Chromosome . Localizes to site of double-strand breaks. .

Other Product Names

Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2' (3') -polynucleotidase) ; Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78) ]

Gene ID (Human)

11284

SwissProt (Human)

Q96T60

Available Sizes

Curated Selection

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