Dactolisib (Tosylate)
Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.
Product Specifications
CAS Number
[1028385-32-1]
Product Name Alternative
BEZ235 (Tosylate) ; NVP-BEZ 235 (Tosylate)
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Autophagy; mTOR; PI3K
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BEZ235-Tosylate.html
Purity
99.87
Solubility
DMSO : 34 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL
Smiles
CN(C1=C2C3=CC(C4=CC5=CC=CC=C5N=C4)=CC=C3N=C1)C(N2C6=CC=C(C=C6)C(C)(C#N)C)=O.CC7=CC=C(S(=O)(O)=O)C=C7
Molecular Formula
C37H31N5O4S
Molecular Weight
641.74
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
MTOR; mTORC1; mTORC2; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Citation 01
Available Sizes
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