Imidazenil

Imidazenil is a partial positive allosteric modulator of GABAA receptors with anxiolytic, antipanic and anticonvulsant activities.

Product Specifications

CAS Number

[151271-08-8]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/imidazenil.html

Purity

98.95

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2CN=C(C3=C(Br)C=CC=C3)C4=C(C=CC(F)=C4)N2C=N1)N

Molecular Formula

C18H12BrFN4O

Molecular Weight

399.22

References & Citations

[1]Giusti P, Ducić I, Puia G, et al. Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors. J Pharmacol Exp Ther. 1993;266 (2) :1018-1028.|[2]Thompson DM, Auta J, Guidotti A, Costa E. Imidazenil, a new anxiolytic and anticonvulsant drug, attenuates a benzodiazepine-induced cognition deficit in monkeys. J Pharmacol Exp Ther. 1995;273 (3) :1307-1312.