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JAK1/2-IN-1

JAK1/2-IN-1 is a potent inhibitor of JAK1 and JAK2, with IC50 values of 0.4 nM and 8.1 nM, respectively. Additionally, JAK1/2-IN-1 inhibits IL-4 and IL-13, with IC50 values of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a) .

Product Specifications

CAS Number

3023876-01-6

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Smiles

C (F) (F) (F) C1=C2C (=CC (NC=3N=C (N[C@@H]4[C@@H] (C#N) CCOC4) C (C) =CN3) =C1) COB2O

Molecular Formula

C19H19BF3N5O3

Molecular Weight

433.19

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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