Amsacrine (gluconate)

Amsacrine gluconate is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.

Product Specifications

CAS Number

[80277-07-2]

Product Name Alternative

M-AMSA (gluconate) ; Acridinyl anisidide (gluconate)

UNSPSC

12352005

Target

Autophagy; Topoisomerase

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amsacrine-gluconate.html

Smiles

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.COC(C=C(C=C1)NS(C)(=O)=O)=C1NC2=C(C=CC=C3)C3=NC4=C2C=CC=C4

Molecular Formula

C27H31N3O10S

Molecular Weight

589.61

References & Citations

[1]Thomas D, et al. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142 (3) :485-94.|[2]Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33 (6) :426-33.|[3]Kao-Shan CS, et al. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat Rep. 1984 Jul-Aug;68 (7-8) :989-97.|[4]Lee YC, et al. Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis. 2016 Oct 19