Amsacrine (gluconate)
Product Specifications
UNSPSC Description
Amsacrine gluconate is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.
Target Antigen
Autophagy; Topoisomerase
Type
Reference compound
Related Pathways
Autophagy;Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amsacrine-gluconate.html
Smiles
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.COC(C=C(C=C1)NS(C)(=O)=O)=C1NC2=C(C=CC=C3)C3=NC4=C2C=CC=C4
Molecular Weight
589.61
References & Citations
[1]Thomas D, et al. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94.|[2]Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33(6):426-33.|[3]Kao-Shan CS, et al. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat Rep. 1984 Jul-Aug;68(7-8):989-97.|[4]Lee YC, et al. Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis. 2016 Oct 19
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13551B/Amsacrine-gluconate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13551B/
Clinical Information
Phase 3
CAS Number
80277-07-2
Curated Selection
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