Ammonium chloride-15N

Ammonium chloride-15N is the 15N labeled Ammonium chloride (HY-Y1269) . Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor[1][2][3].

Product Specifications

CAS Number

[39466-62-1]

UNSPSC

12352100

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ammonium-chloride-15n.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

Cl[15NH4]

Molecular Formula

ClH4 15N

Molecular Weight

54.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Huang X, et al. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci. 2019;227:94-100.|[2]Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219 (4587) :987-988. |[3]Yu C, et al. Lysosome dysfunction enhances oxidative stress-induced apoptosis through ubiquitinated protein accumulation in Hela cells. Anat Rec (Hoboken) . 2013 Jan;296 (1) :31-9.