HDAC6-IN-31

HDAC6-IN-31 (compound 8m) is a selective HDAC6 inhibitor with an IC50 of 0.026 μM. It significantly suppresses the production and release of pro-inflammatory cytokines. HDAC6 plays a crucial role in inhibiting inflammasome activation and holds potential for treating NLRP3 inflammasome-driven inflammatory diseases. Additionally, HDAC6-IN-31 inhibits the migration of glioblastoma cells.