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CSC-6

CSC-6 is an inhibitor of NLRP3. It significantly reduces the secretion of IL-1β in PMATHP-1 cells, with an IC50 of 2.3 μM. CSC-6 specifically binds to NLRP3 and prevents its activation by obstructing ASC oligomerization during the NLRP3 assembly process. It effectively alleviates symptoms of sepsis and gout mediated by excessive NLRP3 activation in mouse models.

Product Specifications

Field of Research

Immunology & Inflammation

Molecular Formula

C18H12F3NO2S2

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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