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(Rac) -BDA-366

(Rac) -BDA-366 (example 2) is the racemate of BDA-366, a potent Bcl-2 antagonist with a Ki of 3.3 nM. It shows high affinity and selectivity for the Bcl-2-BH4 domain. BDA-366 induces a conformational change in Bcl-2, neutralizing its anti-apoptotic function and converting Bcl-2 from a survival molecule into a cell death inducer. Additionally, BDA-366 can inhibit the growth of lung cancer cells.

Product Specifications

CAS Number

142645-19-0

Field of Research

Cell Biology, Signal Transduction

Smiles

O=C1C=2C=CC=CC2C (=O) C=3C (=CC=C (NCC (O) CN (CC) CC) C13) NCC4OC4

Molecular Formula

C24H29N3O4

Molecular Weight

423.50

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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