(Rac) -BDA-366
(Rac) -BDA-366 (example 2) is the racemate of BDA-366, a potent Bcl-2 antagonist with a Ki of 3.3 nM. It shows high affinity and selectivity for the Bcl-2-BH4 domain. BDA-366 induces a conformational change in Bcl-2, neutralizing its anti-apoptotic function and converting Bcl-2 from a survival molecule into a cell death inducer. Additionally, BDA-366 can inhibit the growth of lung cancer cells.
Product Specifications
CAS Number
142645-19-0
Field of Research
Cell Biology, Signal Transduction
Smiles
O=C1C=2C=CC=CC2C (=O) C=3C (=CC=C (NCC (O) CN (CC) CC) C13) NCC4OC4
Molecular Formula
C24H29N3O4
Molecular Weight
423.50
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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