Steffimycin B
Steffimycin B is an anthracycline bacterial metabolite initially isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine. Steffimycin B exhibits cytotoxicity against MCF-7, KB, NCI-H187, and Vero cells with IC50 values of 3.5, 6.75, 3.28, and 10.5 μM, respectively. It also shows activity against *Mycobacterium tuberculosis* (MIC=5.2 nM), *Bacillus cereus* (MIC=1.56 μg/mL), and *Plasmodium falciparum* (IC50=2.19 μM) .
Product Specifications
CAS Number
54526-94-2
Field of Research
Infectious Disease & Virology
Smiles
O ([C@@H]1C2=C (C=C3C (=C2O) C (=O) C=4C (C3=O) =CC (OC) =CC4O) C (=O) [C@@] (C) (O) [C@H]1OC) [C@H]5[C@H] (OC) [C@H] (O) [C@@H] (OC) [C@H] (C) O5
Molecular Formula
C29H32O13
Molecular Weight
588.56
Storage Conditions
-20°C
Notes
For research use only.
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