Thalidomide-O-C3-azide
Thalidomide-O-C3-azide is a chemically modified version of the cereblon (CRBN) inhibitor Thalidomide through click chemistry. It features an azido group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Thalidomide-O-C3-azide serves as a ligand for E3 ubiquitin ligase and a component in E3 Ligase Ligand-Linker Conjugates, facilitating the synthesis of PROTACs.
Product Specifications
CAS Number
2758432-00-5
Field of Research
Pharmacology & Drug Discovery
Smiles
[N-]=[N+]=NCCCOC1=CC=CC=2C (=O) N (C (=O) C12) C3C (=O) NC (=O) CC3
Molecular Formula
C16H15N5O5
Molecular Weight
357.32
Storage Conditions
-20°C
Notes
For research use only.
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